Quinine (QN) is widely used as a flavoring additive in tonic beverages, but excessive intake poses potential health risks, necessitating rapid and reliable on-site monitoring. Here, we report a smartphonebased, dual fluorescent–colorimetric aptasensor (FCApt) that enables quantification of QN within...
Three pairs of intriguing triterpenoid enantiomers, named (-)-onocerin (1), (+)-onocerin (2), (-)-onocerin A (3), (+)-onocerin A (4), (-)-onocerin B (5), (+)-onocerin B (6), together with two biogenetically related triterpenoids, 3β,21α-dihydroxy-serrat-14-en-16-one (7) and serrat-14-ene-3β,21α-diol...
A catalyst-free, visible light-mediated system for the construction of C–N bonds via N–H insertion is reported. The reaction is performed using N-tosylhydrazones and amines under blue LED light at ambient temperature, to produce N-alkylated compounds up to 99% yield. The procedure is applicable to a...
Proteins capable of switching between distinct active states in response to biochemical cues are ideal for sensing and controlling biological processes. Activatable CRISPR-Cas systems are significant in precise genetic manipulation and sensitive molecular diagnostics, yet directly controlling Cas pr...
The efficient and robust signal reporting ability of CRISPR-Cas system exhibits huge value in biosensing, but its applicability for non-nucleic acid analyte detection relies on the coupling of additional recognition modules. To address this limitation, we described a switchable Cas12a and exploited ...