论文成果

Engineering Anti-CRISPR Proteins to Create CRISPR-Cas Protein Switches for Activatable Genome Editing and Viral Protease Detection

Wenyuan Kang ; Fei Xiao; Xi Zhu; Xinyu Ling; Shiyi Xie; Ruimiao Li; Peihang Yu; Linxin Cao; Chunyang Lei; Ye Qiu; Tao Liu; Zhou Nie

Angewandte Chemie (2024) Vol. 2024 pp. e202400599

Proteins capable of switching between distinct active states in response to biochemical cues are ideal for sensing and controlling biological processes. Activatable CRISPR-Cas systems are significant in precise genetic manipulation and sensitive molecular diagnostics, yet directly controlling Cas pr...

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